The X-ray structure of a divergent cyclophilin from the nematode parasite Brugia malayi

Taylor, P., Page, A. P., Kontopidis, G., Husi, H. and Walkinshaw, M. D. (1998) The X-ray structure of a divergent cyclophilin from the nematode parasite Brugia malayi. FEBS Letters, 425(2), pp. 361-366. (doi:10.1016/S0014-5793(98)00264-6) (PMID:9559680)

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Abstract

A structure of residues 1-177 of the cyclophilin domain of a large divergent cyclophilin from the filarial nematode parasite Brugia malayi has been crystallised and solved in two different crystal forms. The active site has a similar structure to that of human cyclophilin A. Two of the 13 residues important in forming the human cyclophilin A/cyclosporin A complex are altered in the B. malayi cyclophilin and explain the relatively poor inhibition of peptidyl prolyl isomerase activity by cyclosporin A.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Husi, Dr Holger
Authors: Taylor, P., Page, A. P., Kontopidis, G., Husi, H., and Walkinshaw, M. D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:FEBS Letters
Publisher:Elsevier
ISSN:0014-5793
ISSN (Online):1873-3468

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