Protein interactome of muscle invasive bladder cancer

Bhat, A. et al. (2015) Protein interactome of muscle invasive bladder cancer. PLoS ONE, 10(1), e0116404. (doi: 10.1371/journal.pone.0116404) (PMID:25569276) (PMCID:PMC4287622)

128435.pdf - Published Version
Available under License Creative Commons Attribution.



Muscle invasive bladder carcinoma is a complex, multifactorial disease caused by disruptions and alterations of several molecular pathways that result in heterogeneous phenotypes and variable disease outcome. Combining this disparate knowledge may offer insights for deciphering relevant molecular processes regarding targeted therapeutic approaches guided by molecular signatures allowing improved phenotype profiling. The aim of the study is to characterize muscle invasive bladder carcinoma on a molecular level by incorporating scientific literature screening and signatures from omics profiling. Public domain omics signatures together with molecular features associated with muscle invasive bladder cancer were derived from literature mining to provide 286 unique protein-coding genes. These were integrated in a protein-interaction network to obtain a molecular functional map of the phenotype. This feature map educated on three novel disease-associated pathways with plausible involvement in bladder cancer, namely Regulation of actin cytoskeleton, Neurotrophin signalling pathway and Endocytosis. Systematic integration approaches allow to study the molecular context of individual features reported as associated with a clinical phenotype and could potentially help to improve the molecular mechanistic description of the disorder.

Item Type:Articles (Other)
Additional Information:: This work was supported by Marie Curie Actions — BCMolMed under grant agreement no. FP7-PEOPLE-2012-ITN-EID and the European Community’s Seventh Framework Programme under grant agreement no. 306157.
Glasgow Author(s) Enlighten ID:Bhat, Dr Akshay and Husi, Dr Holger and Mischak, Professor Harald
Authors: Bhat, A., Heinzel, A., Mayer, B., Perco, P., Mühlberger, I., Husi, H., Merseburger, A. S., Zoidakis, J., Vlahou, A., Schanstra, J. P., Mischak, H., and Jankowski, V.
Subjects:Q Science > QH Natural history > QH345 Biochemistry
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
Journal Name:PLoS ONE
Publisher:Public Library of Science
ISSN (Online):1932-6203
Copyright Holders:Copyright © 2015 Bhat et al.
First Published:First published in PLoS ONE 10(1): e0116404
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record