Pre-trilostane and 3-hour post-trilostane cortisol to monitor trilostane therapy in dogs

Macfarlane, L., Parkin, T. and Ramsey, I. (2016) Pre-trilostane and 3-hour post-trilostane cortisol to monitor trilostane therapy in dogs. Veterinary Record, 179(23), 597. (doi: 10.1136/vr.103744) (PMID:27803375)

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It is recommended that trilostane therapy of canine hyperadrenocorticism is monitored using an ACTH stimulation test, however this has never been validated. Three cortisol concentrations (pre-trilostane, 3-hour posttrilostane and 1-hour post-ACTH stimulation) were compared to a clinical score obtained from an owner questionnaire. There were 110 sets of 3 cortisol measurements and questionnaires obtained from 67 trilostane treated dogs. Questionnaire results were used to classify each dog as well or unwell. Well dogs were then categorised as having excellent, moderate or poor hyperadrenocorticism control, using thresholds produced by 14 independent veterinarians. Correlation co-efficients were used to compare the three cortisol concentrations to the owner score and the Kruskal Wallis and Mann-Whitney U tests were used to compare the three cortisol concentrations between categories of control. Cortisol cut-off values between significantly different categories were determined using ROC curves. Pre-trilostane and 3-hour post-trilostane cortisol were better correlated to the owner score and had cut-offs to differentiate between categories of control that had superior sensitivity and specificity results, than the post-ACTH cortisol. Iatrogenic hypoadrenocorticism was not detected in any unwell dog. This study shows that the pre-trilostane and 3-hour post-trilostane cortisol are potentially better monitoring methods than the ACTH stimulation test.

Item Type:Articles
Additional Information:This study was funded by Dechra Veterinary Products.
Glasgow Author(s) Enlighten ID:Parkin, Professor Tim and Ramsey, Professor Ian
Authors: Macfarlane, L., Parkin, T., and Ramsey, I.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Veterinary Record
Publisher:BMJ Publishing Group
ISSN (Online):2042-7670
Published Online:01 November 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Veterinary Record 179(23): 597
Publisher Policy:Reproduced under a Creative Commons License

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