Biological analysis of human CML stem cells; xenograft model of chronic phase human chronic myeloid leukemia

Abraham, S. A. (2016) Biological analysis of human CML stem cells; xenograft model of chronic phase human chronic myeloid leukemia. In: Li, S. and Zhang, H. (eds.) Chronic Myeloid Leukemia: Methods and Protocols. Series: Methods in molecular biology (1465). Humana Press, pp. 175-185. ISBN 9781493940097 (doi:10.1007/978-1-4939-4011-0_15)

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Abstract

Xenograft mouse models have been instrumental in expanding our knowledge of hematopoiesis and can provide a functional description of stem cells that possess engrafting potential. Here we describe methodology outlining one way of analyzing human malignant cells that are able to engraft immune compromised mice. Using models such as these will allow researchers to gain valuable insight into the primitive leukemic subtypes that evade current therapy regimes and are critical to understand, in order to eradicate malignancy

Item Type:Book Sections
Status:Published
Glasgow Author(s) Enlighten ID:Abraham, Dr Sheela
Authors: Abraham, S. A.
Subjects:?? Chronic myeloid leukemia ??
?? Engraftment ??
?? Immune compromised ??
?? Mouse ??
?? NSG ??
?? Xenograft ??
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Methods in molecular biology (Clifton, N.J.)
Publisher:Humana Press
ISSN:1940-6029
ISBN:9781493940097

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