Synthesis of the tricyclic core of the marine natural product labiatin A

Clark, J.S. , Baxter, C. A. and Castro, J. L. (2005) Synthesis of the tricyclic core of the marine natural product labiatin A. Synthesis(19), pp. 3398-3404. (doi:10.1055/s-2005-918485)

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Publisher's URL: http://dx.doi.org/10.1055/s-2005-918485

Abstract

A synthetic route to a model of the tricyclic core of labiatin A is described. Two catalytic metal carbenoid reactions, C-H insertion and oxonium ylide generation with subsequent [2,3]-sigmatropic rearrangement, have been used to assemble the tricyclic system in an efficient and stereoselective manner.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Clark, Professor Stephen
Authors: Clark, J.S., Baxter, C. A., and Castro, J. L.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Synthesis
Publisher:Georg Thieme Verlag
ISSN:0039-7881
ISSN (Online):1437-210X

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
451781Total synthesis of the lytophynins ether-bridged cembranoid natural products of marine origin.Stephen ClarkEngineering & Physical Sciences Research Council (EPSRC)GR/T21905/01SCHOOL OF CHEMISTRY