Mindfulness-based stress reduction in Parkinson's disease: a systematic review

McLean, G., Lawrence, M., Simpson, R. and Mercer, S.W. (2017) Mindfulness-based stress reduction in Parkinson's disease: a systematic review. BMC Neurology, 17, 92. (doi:10.1186/s12883-017-0876-4) (PMID:28506263) (PMCID:PMC5433018)

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Abstract

Background: Mindfulness based stress reduction (MBSR) is increasingly being used to improve outcomes such as stress and depression in a range of long-term conditions (LTCs). While systematic reviews on MBSR have taken place for a number of conditions there remains limited information on its impact on individuals with Parkinson’s disease (PD). Methods: Medline, Central, Embase, Amed, CINAHAL were searched in March 2016. These databases were searched using a combination of MeSH subject headings where available and keywords in the title and abstracts. We also searched the reference lists of related reviews. Study quality was assessed based on questions from the Cochrane Collaboration risk of bias tool. Results: Two interventions and three papers with a total of 66 participants were included. The interventions were undertaken in Belgium (n = 27) and the USA (n = 39). One study reported significantly increased grey matter density (GMD) in the brains of the MBSR group compared to the usual care group. Significant improvements were reported in one study for a number of outcomes including PD outcomes, depression, mindfulness, and quality of life indicators. Only one intervention was of reasonable quality and both interventions failed to control for potential confounders in the analysis. Adverse events and reasons for drop-outs were not reported. There was also no reporting on the costs/benefits of the intervention or how they affected health service utilisation. Conclusion: This systematic review found limited and inconclusive evidence of the effectiveness of MBSR for PD patients. Both of the included interventions claimed positive effects for PD patients but significant outcomes were often contradicted by other results. Further trials with larger sample sizes, control groups and longer follow-ups are needed before the evidence for MBSR in PD can be conclusively judged.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McLean, Dr Gary and Mercer, Professor Stewart and Simpson, Dr Robert
Authors: McLean, G., Lawrence, M., Simpson, R., and Mercer, S.W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > General Practice and Primary Care
Journal Name:BMC Neurology
Publisher:BioMed Central
ISSN:1471-2377
ISSN (Online):1471-2377
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in BMC Neurology 17:92
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
703811Seedcorn funding for Living Well with MultimorbidityStewart MercerThe RS Macdonald Charitable Trust (RMACDONALD)UNSPECIFIEDIHW - GENERAL PRACTICE & PRIMARY CARE