Fas-independent apoptosis in T-cell tumours induced by the CD2-myc transgene

Cameron, E.R. , Morton, J. , Johnston, C.J., Irvine, J., Bell, M., Onions, D.E., Neil, J.C. , Campbell, M. and Blyth, K. (2000) Fas-independent apoptosis in T-cell tumours induced by the CD2-myc transgene. Cell Death and Differentiation, 7(1), pp. 80-88. (doi: 10.1038/sj.cdd.4400630) (PMID:10713723)

Full text not currently available from Enlighten.

Abstract

Depending on the cellular context, the Myc oncoprotein is capable of promoting cell proliferation or death by apoptosis. These observations suggest that apoptosis in response to deregulated gene expression may represent a natural brake to tumour development. The pathways by which Myc induces apoptosis are as yet poorly characterised although recent observations on rat fibroblasts over-expressing Myc have demonstrated a requirement for the Fas pathway. To investigate the role of Fas in Myc-induced lymphomagenesis we backcrossed CD2-myc mice onto an lpr background. Rates of tumour development and phenotypic properties, including levels of apoptosis were indistinguishable from CD2-myc controls. Further, tumour cell lines derived from mice expressing a regulatable form of Myc showed inducible apoptosis at similar rates regardless of their lpr genotype. These results show that activation of c-myc and loss of Fas do not collaborate in T lymphoma development and that Myc-induced apoptosis in T-cells occurs by Fas-independent pathways.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Blyth, Professor Karen and Cameron, Professor Ewan and Morton, Professor Jen and Neil, Professor James and Onions, Professor David
Authors: Cameron, E.R., Morton, J., Johnston, C.J., Irvine, J., Bell, M., Onions, D.E., Neil, J.C., Campbell, M., and Blyth, K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Cell Death and Differentiation
Publisher:Nature Publishing Group
ISSN:1350-9047
ISSN (Online):1476-5403

University Staff: Request a correction | Enlighten Editors: Update this record