Metabolic regulation by p53 family members

Berkers, C. R., Maddocks, O. D.K. , Cheung, E. C., Mor, I. and Vousden, K. H. (2013) Metabolic regulation by p53 family members. Cell Metabolism, 18(5), pp. 617-633. (doi: 10.1016/j.cmet.2013.06.019) (PMID:23954639) (PMCID:PMC3824073)

Abstract

The function of p53 is best understood in response to genotoxic stress, but increasing evidence suggests that p53 also plays a key role in the regulation of metabolic homeostasis. p53 and its family members directly influence various metabolic pathways, enabling cells to respond to metabolic stress. These functions are likely to be important for restraining the development of cancer but could also have a profound effect on the development of metabolic diseases, including diabetes. A better understanding of the metabolic functions of p53 family members may aid in the identification of therapeutic targets and reveal novel uses for p53-modulating drugs.

• Item Type: Articles
• Additional Information: This work was funded by Cancer Research UK and the European Research Council. C.R.B. is financially supported by a Rubicon Fellowship from the Netherlands Organisation for Scientific Research, and E.C.C. is supported by a Canadian Institutes of Health Research fellowship.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Cheung, Mr Eric and Berkers, Dr Celia and Maddocks, Professor Oliver and Mor, Dr Inbal and Vousden, Karen
• Authors: Berkers, C. R., Maddocks, O. D.K., Cheung, E. C., Mor, I., and Vousden, K. H.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Cell Metabolism
• Publisher: Elsevier (Cell Press)
• ISSN: 1550-4131
• ISSN (Online): 1932-7420
• Published Online: 16 August 2013
• Copyright Holders: Copyright © 2013 The Authors
• First Published: First published in Cell Metabolism 18(5):617-633
• Publisher Policy: Reproduced under a creative commons license