Silybin reduces lipid peroxidation of rat hepatocyte membrane caused by cyclosporin A

Moulisová, V. , Srbová, M., Jedlicková, O., Šebestian, J. and Jegorov, A. (2006) Silybin reduces lipid peroxidation of rat hepatocyte membrane caused by cyclosporin A. Biochemistry (Moscow), 71(10), pp. 1110-1114. (doi: 10.1134/S0006297906100087) (PMID:17125459)

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Abstract

An effect of cyclosporin A on lipid peroxidation in isolated rat hepatocytes was tested. A significant increase in lipid peroxidation marker (the concentration of lipofuscin-like pigments) was observed in samples incubated with cyclosporin A in comparison with the control. When hepatoprotective flavonoid silybin was added, the production of lipofuscin-like pigments decreased significantly. This result indicates a potential positive role of silybin in lowering of cyclosporin A side effects associated with the production of reactive oxygen species and plasma membrane damage.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Moulisova, Dr Vladimira
Authors: Moulisová, V., Srbová, M., Jedlicková, O., Šebestian, J., and Jegorov, A.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Biochemistry (Moscow)
Publisher:Springer Verlag
ISSN:0006-2979
ISSN (Online):1608-3040

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