Moulisová, V. , Srbová, M., Jedlicková, O., Šebestian, J. and Jegorov, A. (2006) Silybin reduces lipid peroxidation of rat hepatocyte membrane caused by cyclosporin A. Biochemistry (Moscow), 71(10), pp. 1110-1114. (doi: 10.1134/S0006297906100087) (PMID:17125459)
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Abstract
An effect of cyclosporin A on lipid peroxidation in isolated rat hepatocytes was tested. A significant increase in lipid peroxidation marker (the concentration of lipofuscin-like pigments) was observed in samples incubated with cyclosporin A in comparison with the control. When hepatoprotective flavonoid silybin was added, the production of lipofuscin-like pigments decreased significantly. This result indicates a potential positive role of silybin in lowering of cyclosporin A side effects associated with the production of reactive oxygen species and plasma membrane damage.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Moulisova, Dr Vladimira |
Authors: | Moulisová, V., Srbová, M., Jedlicková, O., Šebestian, J., and Jegorov, A. |
College/School: | College of Science and Engineering > School of Engineering > Biomedical Engineering |
Journal Name: | Biochemistry (Moscow) |
Publisher: | Springer Verlag |
ISSN: | 0006-2979 |
ISSN (Online): | 1608-3040 |
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