Capillary-based multiplexed isothermal nucleic acid-based test for sexually transmitted diseases in patients

Xu, G., Zhao, H., Cooper, J. M. and Reboud, J. (2016) Capillary-based multiplexed isothermal nucleic acid-based test for sexually transmitted diseases in patients. Chemical Communications, 52(82), pp. 12187-12190. (doi:10.1039/C6CC05679B) (PMID:27722490) (PMCID:PMC5058349)

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Abstract

We demonstrate a multiplexed loop mediated isothermal amplification (LAMP) assay for infectious disease diagnostics, where the analytical process flow of target pathogens genomic DNA is performed manually by moving magnetic beads through a series of plugs in a capillary. Heat is provided by a water bath and the results read by the naked eye, enabling applications in low resource settings.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cooper, Professor Jonathan and Reboud, Dr Julien and Xu, Mr Gaolian
Authors: Xu, G., Zhao, H., Cooper, J. M., and Reboud, J.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Chemical Communications
Publisher:Royal Society of Chemistry
ISSN:1359-7345
ISSN (Online):1364-548X
Published Online:08 September 2016
Copyright Holders:Copyright © 2016 The Royal Society of Chemistry
First Published:First published in Chemical Communications 52(82): 12187-12190
Publisher Policy:Reproduced under a Creative Commons License
Data DOI:10.5525/gla.researchdata.349

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
617021Advanced Diagnostics using PhononicsJonathan CooperEngineering & Physical Sciences Research Council (EPSRC)EP/K027611/1ENG - BIOMEDICAL ENGINEERING