Plasma cell malignancy in the acquired immune deficiency syndrome. Association with Epstein-Barr virus

Voelkerding, K. V., Sandhaus, L. M., Kim, H. C., Wilson, J. , Chittenden, T., Levine, A. J. and Raska, K. (1989) Plasma cell malignancy in the acquired immune deficiency syndrome. Association with Epstein-Barr virus. American Journal of Clinical Pathology, 92(2), pp. 222-8. (PMID:2547309)

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Abstract

The development of high-grade, malignant B-cell lymphoma is a well-recognized complication of human immunodeficiency virus (HIV) infection. Plasma cell neoplasms, however, have been rarely encountered in HIV-infected people. This study presents the morphologic and immunologic features of an unusual plasma cell tumor occurring in a 31-year-old HIV-antibody-positive male. The malignancy was characterized by widespread dissemination and hypercalcemia at presentation and a clinically aggressive course. Immunoperoxidase staining of tumor tissue obtained from biopsy and at autopsy had positive results for IgM and lambda. In the patient's serum, only an IgG kappa paraprotein was detected, indicating that the tumor was nonsecretory. DNA analysis of autopsy-derived tumor tissues demonstrated clonal rearrangements of the immunoglobulin (Ig) heavy chain gene locus and rearrangements in both kappa and lambda light chain gene loci. Furthermore, DNA hybridization studies revealed the presence of Epstein-Barr virus (EBV) genomes in tumor tissue but not in nontumor tissue from this patient.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Wilson, Dr Joanna
Authors: Voelkerding, K. V., Sandhaus, L. M., Kim, H. C., Wilson, J., Chittenden, T., Levine, A. J., and Raska, K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:American Journal of Clinical Pathology
Publisher:Oxford University Press
ISSN:0002-9173
ISSN (Online):0002-9173

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