Tumors sound the alarmin(s)

Coffelt, S. B. and Scandurro, A. B. (2008) Tumors sound the alarmin(s). Cancer Research, 68(16), pp. 6482-6485. (doi:10.1158/0008-5472.CAN-08-0044) (PMID:18701469) (PMCID:PMC2755533)

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Recent evidence suggests that inflammatory molecules play critical roles in the development and progression of numerous tumors. However, one specific group of inflammatory molecules whose importance has been established in host immune responses, termed alarmins, has been largely overlooked in cancer biology. The function of several alarmins—including the defensins, LL-37, and HMGB1—in tumor development, progression, or suppression is discussed here. Taken together, these studies indicate that alarmins represent potential new targets for manipulation in a variety of tumors

Item Type:Articles
Additional Information:Grant support: NIH (1P20RR20152-01)
Glasgow Author(s) Enlighten ID:Coffelt, Dr Seth
Authors: Coffelt, S. B., and Scandurro, A. B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Cancer Research
Publisher:American Association for Cancer Research
ISSN (Online):1538-7445

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