Coffelt, S. B. and Scandurro, A. B. (2008) Tumors sound the alarmin(s). Cancer Research, 68(16), pp. 6482-6485. (doi: 10.1158/0008-5472.CAN-08-0044) (PMID:18701469) (PMCID:PMC2755533)
Full text not currently available from Enlighten.
Abstract
Recent evidence suggests that inflammatory molecules play critical roles in the development and progression of numerous tumors. However, one specific group of inflammatory molecules whose importance has been established in host immune responses, termed alarmins, has been largely overlooked in cancer biology. The function of several alarmins—including the defensins, LL-37, and HMGB1—in tumor development, progression, or suppression is discussed here. Taken together, these studies indicate that alarmins represent potential new targets for manipulation in a variety of tumors
Item Type: | Articles |
---|---|
Additional Information: | Grant support: NIH (1P20RR20152-01) |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Coffelt, Professor Seth |
Authors: | Coffelt, S. B., and Scandurro, A. B. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Cancer Research |
Publisher: | American Association for Cancer Research |
ISSN: | 0008-5472 |
ISSN (Online): | 1538-7445 |
University Staff: Request a correction | Enlighten Editors: Update this record