Elusive identities and overlapping phenotypes of proangiogenic myeloid cells in tumors

Coffelt, S. B. , Lewis, C. E., Naldini, L., Brown, J. M., Ferrara, N. and De Palma, M. (2010) Elusive identities and overlapping phenotypes of proangiogenic myeloid cells in tumors. American Journal of Pathology, 176(4), pp. 1564-1576. (doi:10.2353/ajpath.2010.090786) (PMID:20167863) (PMCID:PMC2843445)

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Abstract

It is now established that bone marrow-derived myeloid cells regulate tumor angiogenesis. This was originally inferred from studies of human tumor biopsies in which a positive correlation was seen between the number of tumor-infiltrating myeloid cells, such as macrophages and neutrophils, and tumor microvessel density. However, unequivocal evidence was only provided once mouse models were used to examine the effects on tumor angiogenesis by genetically or pharmacologically targeting myeloid cells. Since then, identifying the exact myeloid cell types involved in this process has proved challenging because of myeloid cell heterogeneity and the expression of overlapping phenotypic markers in tumors. As a result, investigators often simply refer to them now as "bone marrow-derived myeloid cells." Here we review the findings of various attempts to phenotype the myeloid cells involved and discuss the therapeutic implications of correctly identifying-and thus being able to target-this proangiogenic force in tumors.

Item Type:Articles
Additional Information:Supported by the Breast Cancer Campaign and Yorkshire Cancer Research, UK (to S.B.C. and C.E.L.), Associazione Italiana per la Ricerca sul Cancro (AIRC) and the European Union (FP6 Tumor-Host Genomics; to L.N. and M.D.P.), and NIH grant RO1 CA128873 (to J.M.B.).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Coffelt, Dr Seth
Authors: Coffelt, S. B., Lewis, C. E., Naldini, L., Brown, J. M., Ferrara, N., and De Palma, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:American Journal of Pathology
Publisher:American Society for Investigative Pathology
ISSN:0002-9440
ISSN (Online):1525-2191
Published Online:16 December 2010

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