Gomez-Roman, N. , Grandori, C.,, Eisenman, R.N. and White, R.J. (2003) Direct activation of RNA polymerase III transcription by c-Myc. Nature, 421(6920), pp. 290-294. (doi: 10.1038/nature01327)
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Publisher's URL: http://dx.doi.org/10.1038/nature01327
Abstract
The proto-oncogene product c-Myc has a direct role in both metazoan cell growth and division. RNA polymerase III (pol III) is involved in the generation of transfer RNA and 5S ribosomal RNA, and these molecules must be produced in bulk to meet the need for protein synthesis in growing cells. We demonstrate here that c-Myc binds to TFIIIB, a pol III-specific general transcription factor, and directly activates pol III transcription. Chromatin immunoprecipitation reveals that endogenous c-Myc is present at tRNA and 5S rRNA genes in cultured mammalian cells. These results suggest that activation of pol III may have a role in the ability of c-Myc to stimulate cell growth
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Gomez-Roman, Dr Maria |
| Authors: | Gomez-Roman, N., Grandori, C.,, Eisenman, R.N., and White, R.J. |
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| College/School: | College of Medical Veterinary and Life Sciences |
| Journal Name: | Nature |
| Publisher: | Nature Publications Group |
| ISSN: | 0028-0836 |
| Copyright Holders: | © Copyright Macmillan Magazines Ltd |
| First Published: | First published in Nature 421:290 - 294 |
| Publisher Policy: | Reproduced with the permission of the Publisher. |
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