p53 and tumour viruses: catching the guardian off-guard

Neil, J. C. , Cameron, E. R. and Baxter, E. W. (1997) p53 and tumour viruses: catching the guardian off-guard. Trends in Microbiology, 5(3), pp. 115-120. (doi:10.1016/S0966-842X(96)10083-4) (PMID:9080610)

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Abstract

Oncogenic viruses have evolved direct and indirect mechanisms to overcome the tumour suppressor p53. Fortunately, tumour development is limited by the narrow cell tropisms of the viruses concerned and the host immune response. However, such viruses are helping to elucidate the p53 response pathway and may play a future role as novel cancer therapeutic agents.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cameron, Professor Ewan and Neil, Professor James
Authors: Neil, J. C., Cameron, E. R., and Baxter, E. W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Trends in Microbiology
Publisher:Elsevier
ISSN:0966-842X
ISSN (Online):1878-4380
Published Online:09 December 1997

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