Env-specific CTL predominate in cats protected from feline immunodeficiency virus infection by vaccination.

Flynn, J.N., Keating, P., Hosie, M.J. , Mackett, M., Stephens, E.B., Beatty, J.A., Neil, J.C. and Jarrett, O. (1996) Env-specific CTL predominate in cats protected from feline immunodeficiency virus infection by vaccination. Journal of Immunology, 157(8), pp. 3658-65. (PMID:8871667)

Full text not currently available from Enlighten.

Publisher's URL: http://jvi.asm.org/content/70/11/7561

Abstract

Animal models of HIV-1 have a key role to play in elucidation of the cellular mechanisms responsible for protective immunity. Vaccination of domestic cats with whole inactivated feline immunodeficiency virus (FIV) elicits virus-neutralizing Abs and virus-specific CTL in the peripheral blood and lymphoid organs and affords protection from homologous virus challenge. In the present study we confirm the induction of virus-specific CTL following immunization with whole inactivated FIV vaccine and demonstrate that cats are protected for up to 1 yr following vaccination. Long term protection in vaccinated cats correlates with both higher levels of FIV Env-specific CTL in the peripheral blood following vaccination and the presence of FIV Env-specific memory CD8+ CTL in the lymph nodes, which persist for up to 1 yr following challenge in the absence of detectable virus. The CTL responses observed in vaccinated protected cats differ qualitatively from those in FIV-infected cats. The latter cats either do not generate a memory CTL response or exhibit a Gag-specific memory CTL response. These results show that the protective immunity observed in whole inactivated virus-vaccinated cats is associated with the induction of high levels of Env-specific CTL activity.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hosie, Professor Margaret and Jarrett, Professor James and Neil, Professor James
Authors: Flynn, J.N., Keating, P., Hosie, M.J., Mackett, M., Stephens, E.B., Beatty, J.A., Neil, J.C., and Jarrett, O.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Journal of Immunology
ISSN:0022-1767
ISSN (Online):1872-7905

University Staff: Request a correction | Enlighten Editors: Update this record