Recombinant feline viruses containing the myc gene rapidly produce clonal tumours expressing T-cell antigen receptor gene transcripts

Onions, D., Lees, G., Forrest, D. and Neil, J.C. (1987) Recombinant feline viruses containing the myc gene rapidly produce clonal tumours expressing T-cell antigen receptor gene transcripts. International Journal of Cancer, 40(1), pp. 40-5. (PMID:3036720)

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Abstract

We, and others, have recently shown that recombinant feline leukaemia viruses (FeLV) containing the myc gene (FeLV-myc) occur in up to 30% of naturally occurring cases of T-cell lymphosarcoma. Investigation of the disease spectrum of two FeLV-myc isolates showed that they induced clonal or oligoclonal T-cell tumours after a short latent period. The phenotypic pattern of the thymic tumours was restricted in that they all expressed the alpha and beta chains of the T-cell antigen receptor and could readily be established in culture in vitro without the addition of exogenous interleukin-2. Although helper FeLV was transmitted from infected cats to uninfected tracer cats, there was no evidence of horizontal transmission of FeLV-myc viruses, suggesting that these viruses arise de novo in individual cases of thymic lymphosarcoma.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Neil, Professor James and Onions, Professor David
Authors: Onions, D., Lees, G., Forrest, D., and Neil, J.C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:International Journal of Cancer
Publisher:John Wiley and Sons
ISSN:0020-7136
ISSN (Online):1097-0215

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