Isolation and characterisation of a myeloid leukaemia inducing strain of feline leukaemia virus

Tzavaras, T., Testa, N., Neil, J. and Onions, D. (1989) Isolation and characterisation of a myeloid leukaemia inducing strain of feline leukaemia virus. In: Modern Trends in Human Leukemia VIII. Series: Haematology and blood transfusion, 32. Springer, pp. 347-351. ISBN 9783540509677 (doi:10.1007/978-3-642-74621-5_60)

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Abstract

Feline leukaemia virus (FeLV) is the aetiological agent of a wide range of neoplastic and degenerative conditions [1]. The predominant, naturally occurring, FeLV-induced tumours are T-cell lymphomas, and recently some of the viral events in their pathogenesis have been elucidated. Both transduction and insertional mutagenesis of the myc gene are frequent concomitants of T-cell transformation by FeLV. In addition, a possible role for the T-cell antigen receptor gene in leukaemogenesis has been revealed with the discovery of an FeLV-mediated transduction of the β-chain of the T-cell antigen receptor [2, 3].

Item Type:Book Sections
Status:Published
Glasgow Author(s) Enlighten ID:Neil, Professor James and Onions, Professor David
Authors: Tzavaras, T., Testa, N., Neil, J., and Onions, D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Publisher:Springer
ISSN:0440-0607
ISBN:9783540509677

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