Isolation and characterisation of a myeloid leukaemia inducing strain of feline leukaemia virus

Tzavaras, T., Testa, N., Neil, J. and Onions, D. (1989) Isolation and characterisation of a myeloid leukaemia inducing strain of feline leukaemia virus. In: Modern Trends in Human Leukemia VIII. Series: Haematology and blood transfusion, 32. Springer, pp. 347-351. ISBN 9783540509677 (doi: 10.1007/978-3-642-74621-5_60)

Abstract

Feline leukaemia virus (FeLV) is the aetiological agent of a wide range of neoplastic and degenerative conditions [1]. The predominant, naturally occurring, FeLV-induced tumours are T-cell lymphomas, and recently some of the viral events in their pathogenesis have been elucidated. Both transduction and insertional mutagenesis of the myc gene are frequent concomitants of T-cell transformation by FeLV. In addition, a possible role for the T-cell antigen receptor gene in leukaemogenesis has been revealed with the discovery of an FeLV-mediated transduction of the β-chain of the T-cell antigen receptor [2, 3].

• Item Type: Book Sections
• Status: Published
• Glasgow Author(s) Enlighten ID: Neil, Professor James and Onions, Professor David
• Authors: Tzavaras, T., Testa, N., Neil, J., and Onions, D.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Publisher: Springer
• ISSN: 0440-0607
• ISBN: 9783540509677