Synthesis of selective inhibitors of sphingosine kinase 1

Baek, D. J., MacRitchie, N., Pyne, N. J., Pyne, S. and Bittman, R. (2013) Synthesis of selective inhibitors of sphingosine kinase 1. Chemical Communications, 49(21), pp. 2136-2138. (doi: 10.1039/C3CC00181D) (PMID:23388656) (PMCID:PMC3608193)

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Abstract

Sphingosine kinase isoform 1 (SK1) inhibitors may serve as therapeutic agents for proliferative diseases, including hypertension. We synthesized a series of sphingosine-based SK1-selective inhibitors, the most potent of which is RB-005 (IC50 = 3.6 μM), which also induced proteasomal degradation of SK1 in human pulmonary arterial smooth muscle cells.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:MacRitchie, Dr Neil
Authors: Baek, D. J., MacRitchie, N., Pyne, N. J., Pyne, S., and Bittman, R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Chemical Communications
Publisher:Royal Society of Chemistry
ISSN:1359-7345
ISSN (Online):1364-548X
Published Online:28 January 2013
Copyright Holders:Copyright © 2013 The Royal Society of Chemistry
First Published:First published in Chemical Communications 49(21): 2136-2138
Publisher Policy:Reproduced under a Creative Commons License

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