Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications

Wu, W. K.K., Wang, G., Coffelt, S. B. , Betancourt, A. M., Lee, C. W., Fan, D., Wu, K., Yu, J., Sung, J. J.Y. and Cho, C. H. (2010) Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications. International Journal of Cancer, 127(8), pp. 1741-1747. (doi:10.1002/ijc.25489) (PMID:20521250) (PMCID:PMC2930073)

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Abstract

Human cathelicidin LL-37, a host defense peptide derived from leukocytes and epithelial cells, plays a crucial role in innate and adaptive immunity. Not only does LL-37 eliminate pathogenic microbes directly but also modulates host immune responses. Emerging evidence from tumor biology studies indicates that LL-37 plays a prominent and complex role in carcinogenesis. Although overexpression of LL-37 has been implicated in the development or progression of many human malignancies, including breast, ovarian and lung cancers, LL-37 suppresses tumorigenesis in gastric cancer. These data are beginning to unveil the intricate and contradictory functions of LL-37. The reasons for the tissue-specific function of LL-37 in carcinogenesis remain to be elucidated. Here, we review the relationship between LL-37, its fragments and cancer progression as well as discuss the potential therapeutic implications of targeting this peptide.

Item Type:Articles
Additional Information:This work was supported by a research grant from National Basic Research Program of China (973 Program, 2010CB529305) awarded to D. Fan, K. Wu, J.J.Y. Sung and J. Yu and NIH 1P20RR20152-01, DOD OC073102 Con- cept Award awarded to A.M. Betancourt.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Coffelt, Dr Seth
Authors: Wu, W. K.K., Wang, G., Coffelt, S. B., Betancourt, A. M., Lee, C. W., Fan, D., Wu, K., Yu, J., Sung, J. J.Y., and Cho, C. H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:International Journal of Cancer
Publisher:Wiley
ISSN:00207136
ISSN (Online):1097-0215

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