Genomic and proteomic profiling for cancer diagnosis in dogs

Morris, J. S. (2016) Genomic and proteomic profiling for cancer diagnosis in dogs. Veterinary Journal, 215, pp. 101-109. (doi:10.1016/j.tvjl.2016.01.003) (PMID:26848120)

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Abstract

Global gene expression, whereby tumours are classified according to similar gene expression patterns or ‘signatures’ regardless of cell morphology or tissue characteristics, is being increasingly used in both the human and veterinary fields to assist in cancer diagnosis and prognosis. Many studies on canine tumours have focussed on RNA expression using techniques such as microarrays or next generation sequencing. However, proteomic studies combining two-dimensional polyacrylamide gel electrophoresis or two-dimensional differential gel electrophoresis with mass spectrometry have also provided a wealth of data on gene expression in tumour tissues. In addition, proteomics has been instrumental in the search for tumour biomarkers in blood and other body fluids.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Morris, Professor Joanna
Authors: Morris, J. S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Veterinary Journal
Publisher:Elsevier
ISSN:1090-0233
ISSN (Online):1532-2971
Published Online:12 January 2016
Copyright Holders:Copyright © 2016 Elsevier
First Published:First published in Veterinary Journal 215:101-109
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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