Harkiss, A. and Sutherland, A. (2016) Recent advances in the synthesis and application of fluorescent α-amino acids. Organic and Biomolecular Chemistry, 14(38), pp. 8911-8921. (doi: 10.1039/C6OB01715K) (PMID:27714204)
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Abstract
Fluorescence spectroscopy has become a powerful technique for probing a range of complex biological processes including enzyme mechanisms and protein-protein interactions. While the application of this technique uses a number of strategies, many of these rely on the use of fluorescent α-amino acids. This review highlights the recent synthetic methods developed for the incorporation of highly conjugated chromophores into the side-chain of α-amino acids and the application of these compounds as probes for imaging in medicine and biology. In particular, the design and synthesis of α-amino acids bearing coumarin, flavone and polyaromatic derived chromophores is described.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Sutherland, Professor Andrew and Harkiss, Dr Alexander |
| Authors: | Harkiss, A., and Sutherland, A. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Organic and Biomolecular Chemistry |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1477-0520 |
| ISSN (Online): | 1477-0539 |
| Published Online: | 30 August 2016 |
| Copyright Holders: | Copyright © 2016 Royal Society of Chemistry |
| First Published: | First published in Organic and Biomolecular Chemistry 14(38):8911-8921 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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