Recent advances in the synthesis and application of fluorescent α-amino acids

Harkiss, A. and Sutherland, A. (2016) Recent advances in the synthesis and application of fluorescent α-amino acids. Organic and Biomolecular Chemistry, 14(38), pp. 8911-8921. (doi: 10.1039/C6OB01715K) (PMID:27714204)

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Fluorescence spectroscopy has become a powerful technique for probing a range of complex biological processes including enzyme mechanisms and protein-protein interactions. While the application of this technique uses a number of strategies, many of these rely on the use of fluorescent α-amino acids. This review highlights the recent synthetic methods developed for the incorporation of highly conjugated chromophores into the side-chain of α-amino acids and the application of these compounds as probes for imaging in medicine and biology. In particular, the design and synthesis of α-amino acids bearing coumarin, flavone and polyaromatic derived chromophores is described.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Sutherland, Professor Andrew and Harkiss, Dr Alexander
Authors: Harkiss, A., and Sutherland, A.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Organic and Biomolecular Chemistry
Publisher:Royal Society of Chemistry
ISSN (Online):1477-0539
Published Online:30 August 2016
Copyright Holders:Copyright © 2016 Royal Society of Chemistry
First Published:First published in Organic and Biomolecular Chemistry 14(38):8911-8921
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
608951Engineering and Physical Sciences Doctoral Training Grant 2012-16Mary Beth KneafseyEngineering & Physical Sciences Research Council (EPSRC)EP/K503058/1VICE PRINCIPAL RESEARCH & ENTERPRISE