Feline leukaemia viruses: molecular biology and pathogenesis

Neil, J.C. and Onions, D.E. (1985) Feline leukaemia viruses: molecular biology and pathogenesis. Anticancer Research, 5(1), pp. 49-63. (PMID:2986521)

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The feline leukaemia virus (FeLV) group represents one of the most important viral pathogens of the domestic cat. In addition, this virus - host system is one of the major experimental models for retroviral pathogenesis. Under natural conditions, the virus is horizontally transmitted through the cat population. The outcome of infection depends on a variety of factors including the virus does encountered and the age and immune status of the host. FeLVs can establish persistent infection, either overt or latent. Degenerative diseases of the haemopoietic system are the most common result of persistent infection and immunosuppression with secondary infection accounts for more deaths than does neoplastic disease. However, more is known about the molecular mechanisms of oncogenesis in this system and there are now numerous examples of field case tumours where FeLV has transduced an oncogene or acted as an insertional mutagen. The factors affecting the relative frequency of these mechanisms are considered as is the possibility that recombinant env gene recombinants play a role in FeLV pathogenesis.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Neil, Professor James and Onions, Professor David
Authors: Neil, J.C., and Onions, D.E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Anticancer Research
Publisher:International Institute of Anticancer Research
ISSN (Online):1791-7530

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