Morphine does not facilitate breast cancer progression in two preclinical mouse models for human invasive lobular and HER2+ breast cancer

Doornebal, C. W., Vrijland, K., Hau, C.-S., Coffelt, S. B. , Ciampricotti, M., Jonkers, J., de Visser, K. E. and Hollmann, M. W. (2015) Morphine does not facilitate breast cancer progression in two preclinical mouse models for human invasive lobular and HER2+ breast cancer. Pain, 156(8), pp. 1424-1432. (doi:10.1097/j.pain.0000000000000136) (PMID:25734987)

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Abstract

Morphine and other opioid analgesics are potent pain-relieving agents routinely used for pain management in patients with cancer. However, these drugs have recently been associated with a worse relapse-free survival in patients with surgical cancer, thus suggesting that morphine adversely affects cancer progression and relapse. In this study, we evaluated the impact of morphine on breast cancer progression, metastatic dissemination, and outgrowth of minimal residual disease. Using preclinical mouse models for metastatic invasive lobular and HER2+ breast cancer, we show that analgesic doses of morphine do not affect mammary tumor growth, angiogenesis, and the composition of tumor-infiltrating immune cells. Our studies further demonstrate that morphine, administered in the presence or absence of surgery-induced tissue damage, neither facilitates de novo metastatic dissemination nor promotes outgrowth of minimal residual disease after surgery. Together, these findings indicate that opioid analgesics can be used safely for perioperative pain management in patients with cancer and emphasize that current standards of “good clinical practice” should be maintained.

Item Type:Articles
Additional Information:This study was supported by an AMC stimulation grantto an MD-medical researchtraining grant from the Netherlands Organization for Health Research and Development (ZonMW AGIKO) and departmental funding. KdV acknowledges support from the Dutch Cancer Society (KWF 2011-5004), the Netherlands Organization for Scientific Research (NWO-VIDI 917.93.307) and the Association for International Cancer Research (AICR 11-0677).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Coffelt, Dr Seth
Authors: Doornebal, C. W., Vrijland, K., Hau, C.-S., Coffelt, S. B., Ciampricotti, M., Jonkers, J., de Visser, K. E., and Hollmann, M. W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Pain
Publisher:Lippincott, Williams & Wilkins
ISSN:0304-3959
ISSN (Online):1872-6623
Published Online:13 February 2015

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