Immune-mediated mechanisms influencing the efficacy of anticancer therapies

Coffelt, S. B. and de Visser, K. E. (2015) Immune-mediated mechanisms influencing the efficacy of anticancer therapies. Trends in Immunology, 36(4), pp. 198-216. (doi: 10.1016/j.it.2015.02.006) (PMID:25857662)

Abstract

Conventional anticancer therapies, such as chemotherapy, radiotherapy, and targeted therapy, are designed to kill cancer cells. However, the efficacy of anticancer therapies is not only determined by their direct effects on cancer cells but also by off-target effects within the host immune system. Cytotoxic treatment regimens elicit several changes in immune-related parameters including the composition, phenotype, and function of immune cells. Here we discuss the impact of innate and adaptive immune cells on the success of anticancer therapy. In this context we examine the opportunities to exploit host immune responses to boost tumor clearing, and highlight the challenges facing the treatment of advanced metastatic disease.

• Item Type: Articles
• Additional Information: S.B.C is supported by a Marie Curie Intra-European Fellowship (BMDCMET 275610) and K.E.dV is funded by a European Research Council Consolidator award (INFLAMET 615300), the Dutch Cancer Society (2011-5004), Worldwide Cancer Research (AICR 11-0677), the Netherlands Organization for Scientific Research NWO VIDI (917.96.307), and the European Union (FP7 MCA-ITN 317445 TIMCC).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Coffelt, Professor Seth
• Authors: Coffelt, S. B., and de Visser, K. E.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Trends in Immunology
• Publisher: Elsevier
• ISSN: 1471-4906
• ISSN (Online): 1471-4981
• Published Online: 06 April 2015
• Copyright Holders: Copyright © 2015 Elsevier
• First Published: First published in Trends in Immunology 36(4):198-216
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher