Revving up dendritic cells while braking PD-L1 to jump-start the cancer-immunity cycle motor

Coffelt, S. B. and de Visser, K. E. (2016) Revving up dendritic cells while braking PD-L1 to jump-start the cancer-immunity cycle motor. Immunity, 44(4), pp. 722-724. (doi:10.1016/j.immuni.2016.03.014) (PMID:27096314)

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Abstract

Although it is successful for some, most melanoma patients are refractory to T cell checkpoint inhibition. In this issue of Immunity, Merad and colleagues (2016) describe a dendritic-cell-based strategy to heighten the efficacy of therapeutic anti-PD-L1 and BRAF inhibitors in mouse melanoma models.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Coffelt, Dr Seth
Authors: Coffelt, S. B., and de Visser, K. E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Immunity
Publisher:Elsevier (Cell Press)
ISSN:1074-7613
ISSN (Online):1097-4180
Published Online:19 April 2016
Copyright Holders:Copyright © 2016 Elsevier
First Published:First published in Immunity 44(4):722-724
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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