Flipping the switch: mechanisms that regulate memory consolidation

Breton, J. and Robertson, E. M. (2014) Flipping the switch: mechanisms that regulate memory consolidation. Trends in Cognitive Sciences, 18(12), pp. 629-634. (doi:10.1016/j.tics.2014.08.005) (PMID:25240672)

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Abstract

Memories can follow different processing routes. For example, some memories are enhanced during wakefulness while the enhancement of others is delayed until sleep. Converging evidence suggests that inhibitory mechanisms can ‘switch off’ a processing route, thereby preventing the consolidation of select memories during wakefulness. This switch arises due to an actively imposed ‘bottleneck’ generated by the brain. Transcranial magnetic stimulation (TMS) can interfere with this bottleneck, allowing multiple memories to be consolidated simultaneously during wakefulness. This bottleneck restricts memory processing, perhaps allowing for the selection of only rewarded, or relevant memories. Overall, this bottleneck makes it necessary to select memories for consolidation, and the state of a switch (‘on’ or ‘off’) determines whether or not a memory is subsequently consolidated. Understanding how memory consolidation is regulated may provide novel therapeutic strategies.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Robertson, Professor Edwin
Authors: Breton, J., and Robertson, E. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Trends in Cognitive Sciences
Publisher:Elsevier (Cell Press)
ISSN:1364-6613
ISSN (Online):1879-307X
Published Online:17 September 2014

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