Coakley, G., Buck, A. H. and Maizels, R. M. (2016) Host parasite communications—Messages from helminths for the immune system: parasite communication and cell-cell interactions. Molecular and Biochemical Parasitology, 208(1), pp. 33-40. (doi: 10.1016/j.molbiopara.2016.06.003) (PMID:27297184)
|
Text
123189.pdf - Published Version Available under License Creative Commons Attribution. 2MB |
Abstract
Helminths are metazoan organisms many of which have evolved parasitic life styles dependent on sophisticated manipulation of the host environment. Most notably, they down-regulate host immune responses to ensure their own survival, by exporting a range of immuno-modulatory mediators that interact with host cells and tissues. While a number of secreted immunoregulatory parasite proteins have been defined, new work also points to the release of extracellular vesicles, or exosomes, that interact with and manipulate host gene expression. These recent results are discussed in the overall context of how helminths communicate effectively with the host organism.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Maizels, Professor Rick |
| Authors: | Coakley, G., Buck, A. H., and Maizels, R. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Molecular and Biochemical Parasitology |
| Publisher: | Elsevier BV |
| ISSN: | 0166-6851 |
| ISSN (Online): | 1872-9428 |
| Published Online: | 11 June 2016 |
| Copyright Holders: | Copyright © 2016 The Authors |
| First Published: | First published in Molecular and Biochemical Parasitology 208(1):33-40 |
| Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record
Funder and Project Information
Funder and Project Information