Microvesicles as vehicles for tissue regeneration: Changing of the guards

Panagiotou, N. , Davies, R. W., Selman, C. and Shiels, P. G. (2016) Microvesicles as vehicles for tissue regeneration: Changing of the guards. Current Pathobiology Reports, 4(4), pp. 181-187. (doi:10.1007/s40139-016-0115-5) (PMID:27882267) (PMCID:PMC5101251)

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Abstract

Purpose of Review: Microvesicles (MVs) have been recognised as mediators of stem cell function, enabling and guiding their regenerative effects. Recent Findings: MVs constitute one unique size class of extracellular vesicles (EVs) directly shed from the cell plasma membrane. They facilitate cell-to-cell communication via intercellular transfer of proteins, mRNA and microRNA (miRNA). MVs derived from stem cells, or stem cell regulatory cell types, have proven roles in tissue regeneration and repair processes. Their role in the maintenance of healthy tissue function throughout the life course and thus in age related health span remains to be elucidated. Summary: Understanding the biogenesis and mechanisms of action of MVs may enable the development of cell-free therapeutics capable of assisting in tissue maintenance and repair for a variety of age-related degenerative diseases. This review critically evaluates recent work published in this area and highlights important new findings demonstrating the use of MVs in tissue regeneration.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Selman, Professor Colin and Shiels, Professor Paul and Panagiotou, Nikolaos
Authors: Panagiotou, N., Davies, R. W., Selman, C., and Shiels, P. G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Current Pathobiology Reports
Publisher:Springer US
ISSN:2167-485X
ISSN (Online):2167-485X
Published Online:27 August 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Current Pathobiology Reports 4(4):181-187
Publisher Policy:Reproduced under a Creative Commons License

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