Pereira-Caro, G., Ludwig, I. A., Polyviou, T., Malkova, D. , Garcia, A. , Moreno-Rojas, J. M. and Crozier, A. (2016) Identification of plasma and urinary metabolites and catabolites derived from orange juice (poly)phenols: analysis by high-performance liquid chromatography–high-resolution mass spectrometry. Journal of Agricultural and Food Chemistry, 64(28), pp. 5724-5735. (doi: 10.1021/acs.jafc.6b02088) (PMID:27339035)
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Abstract
Orange juice is a rich source of (poly)phenols, in particular, the flavanones hesperetin-7-O-rutinoside and naringenin-7-O-rutinoside. Following the acute consumption of 500 mL of orange juice containing 398 μmol of (poly)phenols by 12 volunteers, 0–24 h plasma and urine samples were analyzed by targeted high-performance liquid chromatography–high-resolution mass spectrometry in order to identify flavanone metabolites and phenolic acid and aromatic catabolites. A total of 19 flavanone metabolites—comprising di-O-glucuronide, O-glucuronide, O-glucuronyl-sulfate, and sulfate derivatives of hesperetin, naringenin, and eriodictyol—and 65 microbial-derived phenolic catabolites, such as phenylpropanoid, phenylpropionic, phenylacetic, benzoic, and hydroxycarboxylic acids and benzenetriol and benzoylglycine derivatives, including free phenolics and phase II sulfate, glucuronide, and methyl metabolites, were identified or partially identified in plasma and/or urine samples. The data obtained provide a detailed evaluation of the fate of orange juice (poly)phenols as they pass through the gastrointestinal tract and are absorbed into the circulatory system prior to renal excretion. Potential pathways for these conversions are proposed.
| Item Type: | Articles |
|---|---|
| Additional Information: | G.P.-C. was supported by a postdoctoral research contract funded by IFAPA and ESF. I.L. was supported by a postdoctoral research contract funded by the Spanish Ministry of Economy and Competitiveness (FJCI-2014-20689). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Malkova, Dr Dalia and Polyviou, Dr Thelma and Crozier, Professor Alan and Garcia, Dr Ada |
| Authors: | Pereira-Caro, G., Ludwig, I. A., Polyviou, T., Malkova, D., Garcia, A., Moreno-Rojas, J. M., and Crozier, A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Journal of Agricultural and Food Chemistry |
| Publisher: | American Chemical Society |
| ISSN: | 0021-8561 |
| ISSN (Online): | 1520-5118 |
| Published Online: | 24 June 2016 |
| Copyright Holders: | Copyright © 2016 American Chemical Society |
| First Published: | First published in Journal of Agricultural and Food Chemistry 64(28):5724-5735 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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