Microwave-assisted synthesis of highly crystalline, multifunctional iron oxide nanocomposites for imaging applications

Williams, M. J. et al. (2016) Microwave-assisted synthesis of highly crystalline, multifunctional iron oxide nanocomposites for imaging applications. RSC Advances, 6(87), pp. 83520-83528. (doi: 10.1039/C6RA11819D)

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We report a reproducible single-step, microwave-assisted approach for the preparation of multifunctional magnetic nanocomposites comprising superparamagnetic iron oxide (Fe3O4) cores, a polyelectrolyte stabilizer and an organic dye with no requirement for post-processing. The stabilisers poly(sodium 4-styrenesulfonate) (PSSS) and sodium polyphosphate (SPP) have been thoroughly investigated and from analysis using electron microscopy, dynamic light scattering measurements, magnetic hysteresis and magnetic resonance (MR) imaging, we show that the higher degree of Fe3O4 nanoparticle crystallinity achieved with the PSSS stabiliser leads to enhanced magnetic behaviour and thus better contrast agent relaxivity compared to the less crystalline, poorly defined particles obtained when SPP is employed as a stabiliser. We also demonstrate the potential for obtaining a multifunctional magnetic-fluorescent nanocomposite using our microwave-assisted synthesis. In this manner, we demonstrate the intimate link between synthetic methodology (microwave heating with a polyelectrolyte stabilizer) and the resulting properties (particle size, shape, and magnetism) and how this underpins the functionality of the resulting nanocomposites as agents for biomedical imaging.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Corr, Professor Serena and MacLaren, Dr Donald and Aluri, Miss Ester
Authors: Williams, M. J., Sanchez, E., Aluri, E. R., Douglas, F. J., MacLaren, D. A., Collins, O. M., Cussen, E. J., Budge, J. D., Sanders, L. C., Michaels, M., Smales, C. M., Cinatl, J. J., Lorrio, S., Kreuger, D., de Rosales, R. T. M., and Corr, S.
College/School:College of Science and Engineering > School of Chemistry
College of Science and Engineering > School of Physics and Astronomy
Journal Name:RSC Advances
Publisher:Royal Society of Chemistry
ISSN (Online):2046-2069
Published Online:22 August 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in RSC Advances 6(87):83520-83528
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
643201Microwave processing for fast, green preparation of insertion electrodesSerena CorrEngineering & Physical Sciences Research Council (EPSRC)EP/K029290/1SCHOOL OF CHEMISTRY
651811Multifunctional magnetic nanocomposites for artefact conservationSerena CorrLeverhulme Trust (LEVERHULME)RPG-2015-134SCHOOL OF CHEMISTRY