Factors that affect stabilisation times of canine spontaneous hypoadrenocorticism

Roberts, E., Boden, L.A. and Ramsey, I.K. (2016) Factors that affect stabilisation times of canine spontaneous hypoadrenocorticism. Veterinary Record, 179(4), 98. (doi:10.1136/vr.103663) (PMID:27269282)

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Abstract

The objective of this retrospective study was to examine factors that may have affected the stabilisation times of 50 dogs with spontaneous hypoadrenocorticism that were being treated with fludrocortisone acetate, with particular emphasis on dosing frequency and the concurrent use of prednisolone. Stabilisation was defined as an absence of clinical signs with a sodium:potassium ratio >27:1 and both electrolyte concentrations within a laboratory reference range. It was found that the median time till stabilisation was three months. The frequency of fludrocortisone treatment (once, twice or changed from once to twice a day) had no effect on the stabilisation time. The two groups of dogs that were started and stabilised on once a day or twice a day dosing had a median stabilisation time of two months. However, dogs that failed to stabilise on once a day dosing of fludrocortisone and were then changed onto twice a day dosing then stabilised a median of one month later. Concurrent use of prednisolone resulted in significantly faster stabilisation times. It was concluded that dogs with hypoadrenocorticism should be continued on prednisolone therapy until they are stabilised. If a dog is failing to stabilise on once a day fludrocortisone acetate, a change to twice a day administration could be considered.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ramsey, Professor Ian and Boden, Dr Lisa
Authors: Roberts, E., Boden, L.A., and Ramsey, I.K.
College/School:College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Veterinary Record
Publisher:B M J Group
ISSN:0042-4900
ISSN (Online):2042-7670
Published Online:07 June 2016

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