Development of a conceptual model of disease progression for use in economic modeling of chronic obstructive pulmonary disease

Tabberer, M., Gonzalez-McQuire, S., Muellerova, H., Briggs, A. , Rutten-van Molken, M., Chambers, M. and Lomas, D. A. (2017) Development of a conceptual model of disease progression for use in economic modeling of chronic obstructive pulmonary disease. Medical Decision Making, 37(4), pp. 440-452. (doi:10.1177/0272989X16662009) (PMID:27486218)

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Abstract

Background. To develop and validate a new conceptual model (CM) of chronic obstructive pulmonary disease (COPD) for use in disease progression and economic modeling. The CM identifies and describes qualitative associations between disease attributes, progression and outcomes. Methods. A literature review was performed to identify any published CMs or literature reporting the impact and association of COPD disease attributes with outcomes. After critical analysis of the literature, a Steering Group of experts from the disciplines of health economics, epidemiology and clinical medicine was convened to develop a draft CM, which was refined using a Delphi process. The refined CM was validated by testing for associations between attributes using data from the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE). Results. Disease progression attributes included in the final CM were history and occurrence of exacerbations, lung function, exercise capacity, signs and symptoms (cough, sputum, dyspnea), cardiovascular disease comorbidities, ‘other’ comorbidities (including depression), body composition (body mass index), fibrinogen as a biomarker, smoking and demographic characteristics (age, gender). Mortality and health-related quality of life were determined to be the most relevant final outcome measures for this model, intended to be the foundation of an economic model of COPD. Conclusion. The CM is being used as the foundation for developing a new COPD model of disease progression and to provide a framework for the analysis of patient-level data. The CM is available as a reference for the implementation of further disease progression and economic models.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Briggs, Professor Andrew
Authors: Tabberer, M., Gonzalez-McQuire, S., Muellerova, H., Briggs, A., Rutten-van Molken, M., Chambers, M., and Lomas, D. A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Health Economics and Health Technology Assessment
Journal Name:Medical Decision Making
Journal Abbr.:Med Decis Making
Publisher:SAGE Publications
ISSN:0272-989X
ISSN (Online):1552-681X
Published Online:02 August 2016

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