In vivo proton magnetic resonance spectroscopic imaging of the healthy human brain at 9.4 T: initial experience

Chadzynski, G. L., Pohmann, R., Shajan, G., Kolb, R., Bisdas, S., Klose, U. and Scheffler, K. (2015) In vivo proton magnetic resonance spectroscopic imaging of the healthy human brain at 9.4 T: initial experience. Magnetic Resonance Materials in Physics, Biology and Medicine, 28(3), pp. 239-249. (doi:10.1007/s10334-014-0460-5) (PMID:25248946)

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Abstract

Object: In this study, the feasibility of in vivo proton magnetic resonance spectroscopic imaging (1H MRSI) of the healthy human brain at a field strength of 9.4 T, using conventional acquisition techniques, is examined and the initial experience is summarized. Materials and methods: MRSI measurements were performed on a 9.4 T MR scanner (Siemens, Erlangen, Germany) equipped with head-only gradient insert (AC84, Siemens) and custom-developed, 8-channel transmit/24-channel receive, and 16-channel transmit/31-channel receive coils. Spectra were acquired from the superior part of the human brain with a modified STEAM sequence. Spectral quantification was done with LCModel software. Results: Reasonable quality and signal-to-noise ratio of the acquired spectra allowed reliable quantification of 12 metabolites (Cramer-Rao lower bounds < 20 %), some of which may be difficult to quantify at field strengths below 7 T due to overlapping resonances or low concentrations. Conclusion: While further developments are necessary to minimize chemical shift displacement and homogeneity of the transmit field, it is demonstrated that in vivo 1H MRSI at a field strength of 9.4 T is possible. However, further studies applying up-to-date techniques to overcome high-field specific problems are needed in order to assess the potential gain in sensitivity that may be offered by MRSI at 9.4 T.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gunamony, Dr Shajan
Authors: Chadzynski, G. L., Pohmann, R., Shajan, G., Kolb, R., Bisdas, S., Klose, U., and Scheffler, K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Magnetic Resonance Materials in Physics, Biology and Medicine
Publisher:Springer Berlin Heidelberg
ISSN:0968-5243
ISSN (Online):1352-8661
Published Online:24 September 2014

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