Faecal calprotectin in treated and untreated children with coeliac disease and juvenile idiopathic arthritis

Biskou, O., Gardner-Medwin, J., Mackinder, M., Bertz, M., Clark, C., Svolos, V., Russell, R. K., Edwards, C. A. , McGrogan, P. and Gerasimidis, K. (2016) Faecal calprotectin in treated and untreated children with coeliac disease and juvenile idiopathic arthritis. Journal of Pediatric Gastroenterology and Nutrition, 63(5), e112-e115. (doi:10.1097/MPG.0000000000001384) (PMID:27540707)

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Abstract

The present study aimed to provide evidence on whether children at risk of gastrointestinal inflammation have increased measurements of faecal calprotectin (FC). FC was measured in 232 children; 55 children (n = 11 treatment naïve) with juvenile idiopathic arthritis (JIA), 63 with coeliac disease (CD); 17 with new diagnosis before and after treatment on gluten-free diet and 114 controls. None of the treatment-naive children with JIA had raised FC. Four JIA patients on treatment had a raised FC but in all cases a repeat test was normal. In newly diagnosed patients with CD, the median (interquartile range) FC was higher 36.4 (26–61) than that in controls 25.0 (23–41) mg/kg (P = 0.045) but this significantly decreased 25 (25–25) mg/kg (P = 0.012) after 6 months on gluten-free diet. Random measurements of FC are not raised in children with JIA or CD. A significant elevation of FC in these groups is not explained by their diagnosis and therefore needs further investigation.

Item Type:Articles
Additional Information:This study was funded by the Nutricia Research Foundation and the Glasgow Children’s Hospital Charity.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Russell, Dr Richard and Edwards, Professor Christine and Gardner-Medwin, Dr Janet and Bertz, Mr Martin and Gerasimidis, Dr Konstantinos
Authors: Biskou, O., Gardner-Medwin, J., Mackinder, M., Bertz, M., Clark, C., Svolos, V., Russell, R. K., Edwards, C. A., McGrogan, P., and Gerasimidis, K.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Journal of Pediatric Gastroenterology and Nutrition
Publisher:Lippincott, Williams & Wilkins
ISSN:0277-2116
ISSN (Online):1536-4801
Copyright Holders:Copyright © 2016 Lippincott, Williams and Wilkins
First Published:First published in Journal of Pediatric Gastroenterology and Nutrition 63(5):e112-e115
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
573641A pilot study to investigate the microbiota profile and metabolic activity in the colon of juvenile idiopathic arthritis patients at risk of developing Crohn's diseaseKonstantinos GerasimidisYorkhill Children's Foundation (YORKH-CHIL)L Weaver 13.01.MVLS MED -HUMAN NUTRITION
563231Nutritional Status and Microbiota in Coeliac DiseaseKonstantinos GerasimidisNutricia Research Foundation (NUTRICIA)2011-38MVLS MED -HUMAN NUTRITION