31P CSI of the human brain in healthy subjects and tumor patients at 9.4 T with a three-layered multi-nuclear coil: initial results

Mirkes, C., Shajan, G., Chadzynski, G., Buckenmaier, K., Bender, B. and Scheffler, K. (2016) 31P CSI of the human brain in healthy subjects and tumor patients at 9.4 T with a three-layered multi-nuclear coil: initial results. Magnetic Resonance Materials in Physics, Biology and Medicine, 29(3), pp. 579-589. (doi:10.1007/s10334-016-0524-9) (PMID:26811174)

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Abstract

Objective: Investigation of the feasibility and performance of phosphorus (31P) magnetic resonance spectroscopic imaging (MRSI) at 9.4 T with a three-layered phosphorus/proton coil in human normal brain tissue and tumor. Materials and methods: A multi-channel 31P coil was designed to enable MRSI of the entire human brain. The performance of the coil was evaluated by means of electromagnetic field simulations and actual measurements. A 3D chemical shift imaging approach with a variable repetition time and flip angle was used to increase the achievable signal-to-noise ratio of the acquired 31P spectra. The impact of the resulting k-space modulation was investigated by simulations. Three tumor patients and three healthy volunteers were scanned and differences between spectra from healthy and cancerous tissue were evaluated qualitatively. Results: The high sensitivity provided by the 27-channel 31P coil allowed acquiring CSI data in 22 min with a nominal voxel size of 15 × 15 × 15 mm3. Shimming and anatomical localization could be performed with the integrated four-channel proton dipole array. The amplitudes of the phosphodiesters and phosphoethanolamine appeared reduced in tumorous tissue for all three patients. A neutral or slightly alkaline pH was measured within the brain lesions. Conclusion: These initial results demonstrate that 31P 3D CSI is feasible at 9.4 T and could be performed successfully in healthy subjects and tumor patients in under 30 min.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gunamony, Dr Shajan
Authors: Mirkes, C., Shajan, G., Chadzynski, G., Buckenmaier, K., Bender, B., and Scheffler, K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Magnetic Resonance Materials in Physics, Biology and Medicine
Publisher:Springer Berlin Heidelberg
ISSN:0968-5243
ISSN (Online):1352-8661
Published Online:25 January 2016

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