Role of noncoding RNA in vascular remodelling

Deng, L., Bradshaw, A. C. and Baker, A. H. (2016) Role of noncoding RNA in vascular remodelling. Current Opinion in Lipidology, 27(5), pp. 439-448. (doi: 10.1097/MOL.0000000000000336) (PMID:27472407)

Abstract

Purpose of review: Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are becoming fundamentally important in the pathophysiology relating to injury-induced vascular remodelling. We highlight recent studies that demonstrate the involvement of ncRNAs in vein graft disease, in in-stent restenosis and in pulmonary arterial hypertension, with a particular focus on endothelial cell and vascular smooth muscle cell function. We also briefly discuss the emerging role of exosomal-derived ncRNAs and how this mechanism impacts on vascular function. Recent findings: ncRNAs have been described as novel regulators in the pathophysiology of vascular injury, inflammation, and vessel wall remodelling. In particular, several studies have demonstrated that manipulation of miRNAs can reduce the burden of pathological vascular remodelling. Such studies have also shown that exosomal miRNA-mediated, cell-to-cell communication between endothelial cells and vascular smooth muscle cells is critical in the disease process. In addition to miRNAs, lncRNAs are emerging as regulators of vascular function in health and disease. Although lncRNAs are complex in both their sheer numbers and mechanisms of action, identifying their contribution to vascular disease is essential. Summary: Given the important roles of ncRNAs in vascular injury and remodelling together will their capacity for cell-to-cell communication, manipulating ncRNA might provide novel therapeutic interventions.

• Item Type: Articles
• Additional Information: The review is supported by a Chair grant from British Heart Foundation to A.H.B., a Royal Society of Edinburgh (RSE) Personal Research Fellowship to A.C.B., and a China Scholarship Council PhD Studentship (to L.D.; 201206240013).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Bradshaw, Dr Angela and Baker, Professor Andrew
• Authors: Deng, L., Bradshaw, A. C., and Baker, A. H.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Current Opinion in Lipidology
• Publisher: Lippincott Williams & Wilkins
• ISSN: 0957-9672
• ISSN (Online): 1473-6535
• Copyright Holders: Copyright © 2016 Wolters Kluwer Health, Inc.
• First Published: First published in Current Opinion in Lipidology 27(5): 439-448
• Publisher Policy: Reproduced in accordance with the publisher copyright policy