Metabolite Transport Inside Channeled Porous Scaffolds for Haematopoietic Stem Cell Culture: A Computational Study

Cantini, M. , Fiore, G. B., Redaelli, A. and Soncini, M. (2008) Metabolite Transport Inside Channeled Porous Scaffolds for Haematopoietic Stem Cell Culture: A Computational Study. In: ASME 2008 Summer Bioengineering Conference, Marco Island, Florida, 25-29 June 2008, pp. 481-482. ISBN 9780791843215 (doi:10.1115/SBC2008-192852)

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Abstract

Porous polymeric materials play a key role in regenerative medicine, serving as three-dimensional scaffolds for cell culture. Hence, the definition of their micro-architecture should be regarded as a pivotal design issue, that has to be wittingly addressed while engineering a cell culture system. Computational fluid dynamics techniques (CFD) appear to be very valuable in this respect, since they have been appreciably applied in recent literature as a means to analyze fluid dynamics and mass transport inside scaffold or bioreactor models [1]; moreover, leading researchers in tissue engineering have acknowledged the role of numerical methodology in the issue of defining optimal flow conditions for three-dimensional dynamic culture systems.

Item Type:Conference Proceedings
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cantini, Dr Marco
Authors: Cantini, M., Fiore, G. B., Redaelli, A., and Soncini, M.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
ISBN:9780791843215

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