Matrix protein interactions with synthetic surfaces

Rico Tortosa, P., Cantini, M. , Altankov, G. and Salmeron-Sanchez, M. (2014) Matrix protein interactions with synthetic surfaces. In: Pradas, M.M. and Vicent, M.A. (eds.) Polymers in Regenerative Medicine: Biomedical Applications from Nano- to Macro-Structures. Springer, pp. 91-146. ISBN 9780470596388 (doi:10.1002/9781118356692.ch3)

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Abstract

Based on the hypothesis that material substrates are able to trigger the regeneration of a cell population by making use of tissue engineering techniques. Within the context of the cell-protein-material interaction paradigm, this chapter presents a comprehensive description of the interface between material surfaces and living cells, including protein adsorption, cell adhesion, and matrix remodeling phenomena at the cell-material interface. Cell adhesion involves different physicochemical phenomena, in which several biological molecules participate: extracellular matrix (ECM) proteins, cell membrane proteins, and cytoskeleton proteins. The initial cell–material interaction usually involves the adsorption of proteins such as fibronectin (FN), vitronectin (VN), fibrinogen (FG), representing the so-called soluble matrix proteins in the biological fluids. The adsorption of proteins onto the surface of a biomaterial from the surrounding fluid phase is a complex, dynamic, energy-driven process, controlled by protein properties, material surface properties, and solution conditions.

Item Type:Book Sections
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Salmeron-Sanchez, Professor Manuel and Rico Tortosa, Dr Patricia and Cantini, Dr Marco
Authors: Rico Tortosa, P., Cantini, M., Altankov, G., and Salmeron-Sanchez, M.
College/School:College of Science and Engineering > School of Engineering
College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Polymers in Regenerative Medicine
Publisher:Springer
ISBN:9780470596388
Published Online:30 January 2015

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