Are nestin-positive mesenchymal stromal cells a better source of cells for CNS repair?

Lindsay, S. L. and Barnett, S. C. (2017) Are nestin-positive mesenchymal stromal cells a better source of cells for CNS repair? Neurochemistry International, 107, pp. 101-107. (doi:10.1016/j.neuint.2016.08.001) (PMID:27498150) (PMCID:PMC5455984)

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Abstract

In recent years there has been a great deal of research within the stem cell field which has led to the definition and classification of a range of stem cells from a plethora of tissues and organs. Stem cells, by classification, are considered to be pluri- or multipotent and have both self-renewal and multi-differentiation capabilities. Presently there is a great deal of interest in stem cells isolated from both embryonic and adult tissues in the hope they hold the therapeutic key to restoring or treating damaged cells in a number of central nervous system (CNS) disorders. In this review we will discuss the role of mesenchymal stromal cells (MSCs) isolated from human olfactory mucosa, with particular emphasis on their potential role as a candidate for transplant mediated repair in the CNS. Since nestin expression defines the entire population of olfactory mucosal derived MSCs, we will compare these cells to a population of neural crest derived nestin positive population of bone marrow-MSCs.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Barnett, Professor Susan and Lindsay, Dr Susan
Authors: Lindsay, S. L., and Barnett, S. C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Neurochemistry International
Publisher:Elsevier
ISSN:0197-0186
ISSN (Online):1872-9754
Published Online:03 August 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Neurochemistry International 2016
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
584331Does cellular niche affect the repair potential of mesenchymal stem cells; implications for spinal cord injury?Susan BarnettMedical Research Council (MRC)MR/J004731/1III -IMMUNOLOGY
679211Are mesenchymal stem cells (MSCs) isolated from the olfactory mucosa a better source of cells for treatment of MS than bone marrow MSCsSusan BarnettNational Multiple Sclerosis Society (MSS-NY)RG-1501-02703III -IMMUNOLOGY