Are nestin-positive mesenchymal stromal cells a better source of cells for CNS repair?

Lindsay, S. L. and Barnett, S. C. (2017) Are nestin-positive mesenchymal stromal cells a better source of cells for CNS repair? Neurochemistry International, 107, pp. 101-107. (doi: 10.1016/j.neuint.2016.08.001) (PMID:27498150) (PMCID:PMC5455984)

Abstract

In recent years there has been a great deal of research within the stem cell field which has led to the definition and classification of a range of stem cells from a plethora of tissues and organs. Stem cells, by classification, are considered to be pluri- or multipotent and have both self-renewal and multi-differentiation capabilities. Presently there is a great deal of interest in stem cells isolated from both embryonic and adult tissues in the hope they hold the therapeutic key to restoring or treating damaged cells in a number of central nervous system (CNS) disorders. In this review we will discuss the role of mesenchymal stromal cells (MSCs) isolated from human olfactory mucosa, with particular emphasis on their potential role as a candidate for transplant mediated repair in the CNS. Since nestin expression defines the entire population of olfactory mucosal derived MSCs, we will compare these cells to a population of neural crest derived nestin positive population of bone marrow-MSCs.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Barnett, Professor Susan and Lindsay, Dr Susan
• Authors: Lindsay, S. L., and Barnett, S. C.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Neurochemistry International
• Publisher: Elsevier
• ISSN: 0197-0186
• ISSN (Online): 1872-9754
• Published Online: 03 August 2016
• Copyright Holders: Copyright © 2016 The Authors
• First Published: First published in Neurochemistry International 2016
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
58433	1	Does cellular niche affect the repair potential of mesenchymal stem cells; implications for spinal cord injury?	Susan Barnett	Medical Research Council (MRC)	MR/J004731/1	III -IMMUNOLOGY
67921	1	Are mesenchymal stem cells (MSCs) isolated from the olfactory mucosa a better source of cells for treatment of MS than bone marrow MSCs	Susan Barnett	National Multiple Sclerosis Society (MSS-NY)	RG-1501-02703	III -IMMUNOLOGY