Sharif, S. A.I., Calder, E. D.D., Delolo, F. G. and Sutherland, A. (2016) Synthesis of 5-Amino-2,5-dihydro-1H-benzo[b]azepines using a one-pot multibond forming process. Journal of Organic Chemistry, 81(15), pp. 6697-6706. (doi: 10.1021/acs.joc.6b01357) (PMID:27414232)
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Abstract
Rapid access to allylic trichloroacetimidates bearing a 2-allylaminoaryl group from readily available 2-iodoanilines combined with a one-pot multibond forming process has allowed the efficient synthesis of a series of 5-amino-2,5-dihydro-1H-benzo[b]azepines. The potential of these compounds as synthetic building blocks was demonstrated by the preparation of a late-stage intermediate of the hyponatremia agent, mozavaptan.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Calder, Mr Ewen and Sutherland, Professor Andrew |
Authors: | Sharif, S. A.I., Calder, E. D.D., Delolo, F. G., and Sutherland, A. |
College/School: | College of Science and Engineering > School of Chemistry College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
Journal Name: | Journal of Organic Chemistry |
Publisher: | American Chemical Society |
ISSN: | 0022-3263 |
ISSN (Online): | 1520-6904 |
Published Online: | 14 July 2016 |
Copyright Holders: | Copyright © 2016 The Authors |
First Published: | First published in Journal of Organic Chemistry 81(15):6697-6706 |
Publisher Policy: | Reproduced under a Creative Commons License |
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