Non-contrast renal magnetic resonance imaging to assess perfusion and corticomedullary differentiation in health and chronic kidney disease

Gillis, K. A. , Mccomb, C., Patel, R. K., Stevens, K. K., Schneider, M. P., Radjenovic, A. , Morris, S. T.W., Roditi, G. H., Delles, C. and Mark, P. B. (2016) Non-contrast renal magnetic resonance imaging to assess perfusion and corticomedullary differentiation in health and chronic kidney disease. Nephron, 133(3), pp. 183-192. (doi:10.1159/000447601) (PMID:27362585)

[img]
Preview
Text
121076.pdf - Accepted Version

855kB

Abstract

AIMS Arterial spin labelling (ASL) MRI measures perfusion without administration of contrast agent. While ASL has been validated in animals and healthy volunteers (HVs), application to chronic kidney disease (CKD) has been limited. We investigated the utility of ASL MRI in patients with CKD. METHODS We studied renal perfusion in 24 HVs and 17 patients with CKD (age 22-77 years, 40% male) using ASL MRI at 3.0T. Kidney function was determined using estimated glomerular filtration rate (eGFR). T1 relaxation time was measured using modified look-locker inversion and xFB02;ow-sensitive alternating inversion recovery true-fast imaging and steady precession was performed to measure cortical and whole kidney perfusion. RESULTS T1 was higher in CKD within cortex and whole kidney, and there was association between T1 time and eGFR. No association was seen between kidney size and volume and either T1, or ASL perfusion. Perfusion was lower in CKD in cortex (136 ± 37 vs. 279 ± 69 ml/min/100 g; p < 0.001) and whole kidney (146 ± 24 vs. 221 ± 38 ml/min/100 g; p < 0.001). There was significant, negative, association between T1 longitudinal relaxation time and ASL perfusion in both the cortex (r = -0.75, p < 0.001) and whole kidney (r = -0.50, p < 0.001). There was correlation between eGFR and both cortical (r = 0.73, p < 0.01) and whole kidney (r = 0.69, p < 0.01) perfusion. CONCLUSIONS Significant differences in renal structure and function were demonstrated using ASL MRI. T1 may be representative of structural changes associated with CKD; however, further investigation is required into the pathological correlates of reduced ASL perfusion and increased T1 time in CKD.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Morris, Dr Scott and Patel, Dr Rajan and Mccomb, Dr Christie and Mark, Dr Patrick and Delles, Professor Christian and Gillis, Dr Keith and Roditi, Dr Giles and Stevens, Dr Kate and Schneider, Dr Markus and Radjenovic, Dr Aleksandra
Authors: Gillis, K. A., Mccomb, C., Patel, R. K., Stevens, K. K., Schneider, M. P., Radjenovic, A., Morris, S. T.W., Roditi, G. H., Delles, C., and Mark, P. B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Nephron
Publisher:Karger Publishers
ISSN:2235-3186
ISSN (Online):1423-0186
Published Online:01 July 2016
Copyright Holders:Copyright © 2016 S. Karger AG, Base
First Published:First published in Nephron 133(3):183-192
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

University Staff: Request a correction | Enlighten Editors: Update this record