Orphan proteins of unknown function in the mitochondrial intermembrane space proteome: new pathways and metabolic cross-talk

Nuebel, E., Manganas, P. and Tokatlidis, K. (2016) Orphan proteins of unknown function in the mitochondrial intermembrane space proteome: new pathways and metabolic cross-talk. Biochimica et Biophysica Acta: Molecular Cell Research, 1863(11), pp. 2613-2623. (doi: 10.1016/j.bbamcr.2016.07.004) (PMID:27425144) (PMCID:PMC5404111)

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The mitochondrial intermembrane space (IMS) is involved in protein transport, lipid homeostasis and metal ion exchange, while further acting in signalling pathways such as apoptosis. Regulation of these processes involves protein modifications, as well as stress-induced import or release of proteins and other signalling molecules. Even though the IMS is the smallest sub-compartment of mitochondria, its redox state seems to be tightly regulated. However, the way in which this compartment participates in the cross-talk between the multiple organelles and the cytosol is far from understood. Here we focus on newly identified IMS proteins that may represent future challenges in mitochondrial research. We present an overview of the import pathways, the recently discovered new components of the IMS proteome and how these relate to key aspects of cell signalling and progress made in stem cell and cancer research.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Manganas, Phanee and Tokatlidis, Professor Kostas and Nuebel, Dr Esther
Authors: Nuebel, E., Manganas, P., and Tokatlidis, K.
College/School:College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
Journal Name:Biochimica et Biophysica Acta: Molecular Cell Research
ISSN (Online):0167-4889
Published Online:15 July 2016
Copyright Holders:Copyright © 2016 Elsevier
First Published:First published in Biochimica et Biophysica Acta: Molecular Cell Research 1863(11):2613-2623
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
635181SULSA Chair in Systems Biology - Cathcart ChairRichard CogdellScottish Funding Council (SFC)HR07019RI MOLECULAR CELL & SYSTEMS BIOLOGY
624931Oxidative Folding and Redox Signalling in the Mitochondria Intermembrane Space.Konstantinos TokatlidisRoyal Society (ROYSOC)WM120111RI MOLECULAR CELL & SYSTEMS BIOLOGY
617601Next generation sequencing (NGS) approaches to genotyping in myotonic dystrophy type 1 (ISSF Catalyst Fund)Darren MoncktonWellcome Trust (WELLCOME)097821/Z/11/ZRI MOLECULAR CELL & SYSTEMS BIOLOGY