Influence of timing of morphine administration on postoperative pain and analgesic consumption

Millar, A., Mansfield, M. and Kinsella, J. (1998) Influence of timing of morphine administration on postoperative pain and analgesic consumption. British Journal of Anaesthesia, 81(3), pp. 373-376. (doi:10.1093/bja/81.3.373) (PMID:9861123)

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Abstract

We have investigated if a pre-emptive dose of morphine, given 30 min before skin incision, influenced postoperative pain and morphine consumption after hysterectomy. In a prospective, randomized, double-blind, placebo-controlled clinical study, patients received morphine 0.3 mg kg-1 at induction of anaesthesia or 30 min later at skin incision. The primary endpoint was defined as 24-h morphine consumption via patient-controlled analgesia. We could not demonstrate any difference between the two groups in morphine consumption or pain scores, and we conclude that there was no evidence of pre-emptive analgesia in this study.

Item Type:Articles (Other)
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kinsella, Professor John
Authors: Millar, A., Mansfield, M., and Kinsella, J.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:British Journal of Anaesthesia
Publisher:Oxford University Press
ISSN:0007-0912
ISSN (Online):1471-6771

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