Surrogates, meta-analysis and cost-effectiveness modelling: a combined analytic approach.

Hawkins, N. , Richardson, G., Sutton, A. J., Cooper, N. J., Griffiths, C., Rogers, A. and Bower, P. (2012) Surrogates, meta-analysis and cost-effectiveness modelling: a combined analytic approach. Health Economics, 21(6), pp. 742-756. (doi:10.1002/hec.1741) (PMID:21796723)

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Abstract

Estimates of cost-effectiveness analyses are typically obtained either directly from ‘trial’ based analyses or indirectly via surrogate endpoints in ‘model’ based analyses. Data from clinical trials that include both surrogate and final endpoints can be used in a joint analysis that combines these two approaches. This joint approach allows the inclusion of information regarding the effects of treatment on surrogate endpoints while relaxing the strong assumption of ‘conditional independence’ associated with indirect model-based analyses. An example cost-effectiveness analysis of Chronic Disease Self-Management Programme is used to compare the different approaches. It is shown that despite using a common data set, the different analytic approaches produce differing estimates of the cost-effectiveness of the intervention and the value of future research. The paper concludes by discussing the selection of the appropriate analytic approach.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hawkins, Professor Neil
Authors: Hawkins, N., Richardson, G., Sutton, A. J., Cooper, N. J., Griffiths, C., Rogers, A., and Bower, P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Health Economics and Health Technology Assessment
Journal Name:Health Economics
Publisher:Wiley
ISSN:1057-9230
ISSN (Online):1099-1050
Published Online:28 July 2011

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