Low YKL-40 in Chronic Heart Failure may predict beneficial effects of statins: Analysis from the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA)

Arain, F., Gullestad, L., Nymo, S., Kjekshus, J., Cleland, J. G.F. , Michelsen, A., McMurray, J. J.V. , Wikstrand, J., Aukrust, P. and Ueland, T. (2017) Low YKL-40 in Chronic Heart Failure may predict beneficial effects of statins: Analysis from the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA). Biomarkers, 22, pp. 261-267. (doi:10.1080/1354750X.2016.1204003) (PMID:27325138)

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Abstract

Context and objective: To evaluate if YKL-40 can provide prognostic information in patients with ischemic heart failure (HF) and identify patients who may benefit from statin therapy. Materials and Methods: The association between serum YKL-40 and predefined outcome was evaluated in 1344 HF patients assigned to rosuvastatin or placebo. Results: YKL-40 was not associated with outcome in adjusted analysis. In YKL-40 tertile 1, an effect on the primary outcome (HR 0.50, p = 0.006) and CV death (HR 0.54 p = 0.040) was seen by rosuvastatin in adjusted analysis. Conclusions: A beneficial modification of outcome was observed with statin therapy in patients with low YKL-40 levels.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McMurray, Professor John and Cleland, Professor John
Authors: Arain, F., Gullestad, L., Nymo, S., Kjekshus, J., Cleland, J. G.F., Michelsen, A., McMurray, J. J.V., Wikstrand, J., Aukrust, P., and Ueland, T.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
Journal Name:Biomarkers
Publisher:Taylor & Francis
ISSN:1354-750X
ISSN (Online):1366-5804
Published Online:21 June 2016
Copyright Holders:Copyright © 2016 Informa UK Limited, trading as Taylor & Francis Group
First Published:First published in Biomarkers 22:261-267
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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