Chronic traumatic encephalopathy: the neuropathological legacy of traumatic brain injury

Hay, J., Johnson, V. E., Smith, D. H. and Stewart, W. (2016) Chronic traumatic encephalopathy: the neuropathological legacy of traumatic brain injury. Annual Review of Pathology: Mechanisms of Disease, 11(1), pp. 21-45. (doi:10.1146/annurev-pathol-012615-044116) (PMID:26772317)

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Abstract

Almost a century ago, the first clinical account of the punch-drunk syndrome emerged, describing chronic neurological and neuropsychiatric sequelae occurring in former boxers. Thereafter, throughout the twentieth century, further reports added to our understanding of the neuropathological consequences of a career in boxing, leading to descriptions of a distinct neurodegenerative pathology, termed dementia pugilistica. During the past decade, growing recognition of this pathology in autopsy studies of nonboxers who were exposed to repetitive, mild traumatic brain injury, or to a single, moderate or severe traumatic brain injury, has led to an awareness that it is exposure to traumatic brain injury that carries with it a risk of this neurodegenerative disease, not the sport or the circumstance in which the injury is sustained. Furthermore, the neuropathology of the neurodegeneration that occurs after traumatic brain injury, now termed chronic traumatic encephalopathy, is acknowledged as being a complex, mixed, but distinctive pathology, the detail of which is reviewed in this article.

Item Type:Articles
Additional Information:This work was supported by National Institutes of Health grants NS038104 (D.H.S. and W.S.), NS056202, NS092389, and AG038911 (D.H.S.); United States Department of Defense grant PT110785 (D.H.S. and W.S.); a National Health Service Research Scotland Career Researcher Fellowship (W.S.); and the Sackler Institute (J.H.).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Stewart, Dr William and Hay, Miss Jennifer
Authors: Hay, J., Johnson, V. E., Smith, D. H., and Stewart, W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Annual Review of Pathology: Mechanisms of Disease
Publisher:Annual Reviews
ISSN:1553-4006
ISSN (Online):1553-4014
Published Online:13 January 2016
Copyright Holders:Copyright © 2016 Annual Reviews
First Published:First published in Annual Review of Pathology: Mechanisms of Disease 11(1)):21-45
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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