A compact fiber-optic probe-based singlet oxygen luminescence detection system

Gemmell, N. R., McCarthy, A., Kim, M. M., Veilleux, I., Zhu, T. C., Buller, G. S., Wilson, B. C. and Hadfield, R. H. (2017) A compact fiber-optic probe-based singlet oxygen luminescence detection system. Journal of Biophotonics, 10(2), pp. 320-326. (doi:10.1002/jbio.201600078) (PMID:27455426)

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Abstract

This paper presents a novel compact fiberoptic based singlet oxygen near-infrared luminescence probe coupled to an InGaAs/InP single photon avalanche diode (SPAD) detector. Patterned time gating of the single-photon detector is used to limit unwanted dark counts and eliminate the strong photosensitizer luminescence background. Singlet oxygen luminescence detection at 1270 nm is confirmed through spectral filtering and lifetime fitting for Rose Bengal in water, and Photofrin in methanol as model photosensitizers. The overall performance, measured by the signal-to-noise ratio, improves by a factor of 50 over a previous system that used a fiberoptic-coupled superconducting nanowire single-photon detector. The effect of adding light scattering to the photosensitizer is also examined as a first step towards applications in tissue in vivo.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hadfield, Professor Robert and Gemmell, Mr Nathan
Authors: Gemmell, N. R., McCarthy, A., Kim, M. M., Veilleux, I., Zhu, T. C., Buller, G. S., Wilson, B. C., and Hadfield, R. H.
College/School:College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
Journal Name:Journal of Biophotonics
Publisher:Wiley
ISSN:1864-063X
ISSN (Online):1864-0648
Published Online:25 July 2016

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
6672319UK Quantum Technology Hub in Enhanced Quantum ImagingMiles PadgettEngineering & Physical Sciences Research Council (EPSRC)EP/M01326X/1S&E P&A - PHYSICS & ASTRONOMY