Mechanisms of mitophagy: putting the powerhouse into the doghouse

Riley, J. S. and Tait, S. W.G. (2016) Mechanisms of mitophagy: putting the powerhouse into the doghouse. Biological Chemistry, 397(7), pp. 617-635. (doi:10.1515/hsz-2016-0137) (PMID:27071149)

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Abstract

Since entering our cells in an endosymbiotic event one billion years ago, mitochondria have shaped roles for themselves in metabolism, inflammation, calcium storage, migration, and cell death. Given this critical role in cellular homeostasis it is essential that they function correctly. Equally critical is the ability of a cell to remove damaged or superfluous mitochondria to avoid potential deleterious effects. In this review we will discuss the various mechanisms of mitochondrial clearance, with a particular focus on Parkin/PINK1-mediated mitophagy, discuss the impact of altered mitophagy in ageing and disease, and finally consider potential therapeutic benefits of targeting mitophagy.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Riley, Dr Joel and Tait, Professor Stephen
Authors: Riley, J. S., and Tait, S. W.G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Biological Chemistry
Publisher:De Gruyter
ISSN:1431-6730
ISSN (Online):1437-4315
Published Online:12 August 2016

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