Atypical chemokine receptors and their roles in the resolution of the inflammatory response

Bonecchi, R. and Graham, G. J. (2016) Atypical chemokine receptors and their roles in the resolution of the inflammatory response. Frontiers in Immunology, 7, 224. (doi:10.3389/fimmu.2016.00224)

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Chemokines and their receptors are key mediators of the inflammatory process regulating leukocyte extravasation and directional migration into inflamed and infected tissues. The control of chemokine availability within inflamed tissues is necessary to attain a resolving environment and when this fails chronic inflammation ensues. Accordingly, vertebrates have adopted a number of mechanisms for removing chemokines from inflamed sites to help precipitate resolution. Over the past 15 years, it has become apparent that essential players in this process are the members of the atypical chemokine receptor (ACKR) family. Broadly speaking, this family is expressed on stromal cell types and scavenges chemokines to either limit their spatial availability or to remove them from in vivo sites. Here, we provide a brief review of these ACKRs and discuss their involvement in the resolution of inflammatory responses and the therapeutic implications of our current knowledge.

Item Type:Articles
Additional Information:This study was supported by European Union’s Programs for research, technological development and demonstration under grant agreement TIMER  –  281608 (FP7).
Glasgow Author(s) Enlighten ID:Graham, Professor Gerard
Authors: Bonecchi, R., and Graham, G. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Frontiers in Immunology
ISSN (Online):1664-3224
Published Online:10 June 2016
Copyright Holders:Copyright © 2016 Bonecchi and Graham
First Published:First published in Frontiers in Immunology 7:224
Publisher Policy:Reproduced under a Creative Commons License

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